Skip to: site menu | section menu | main content

Currently viewing: Gender Physiology » Return Home

 

Menu:

 
Return to Member's page

Grzegorz Sowa, PhD

Assistant Professor, Medical Pharmocoloy and Physiology

 

Medical Pharmacology and Physiology
One Hospital Drive, M615E
Columbia, MO 65212
573-884-3188
SowaG@missouri.edu

 

The long term goal of Dr. Sowa's research is better understanding the molecular and cellular aspects of the function of proteins associated with detergent resistant membranes (DRMs).
DRMs are operationally defined based on their insolubility in such mild detergents as Triton X-100 and ability to float in sucrose gradients due to their low buoyant density. DRMs can be divided into two major entities, i.e., lipid rafts and caveolae (60-100nm diameter), which are noncoated flask-shaped invaginations of plasma membrane abundant in proteins called caveolins. Caveolin-1 and -2 are primary focus of my current research. In the past, he has determined that formation of morphologically defined caveolae is necessary for caveolin-1 to inhibit endothelial nitric oxide synthase (eNOS) activity in intact cells (Sowa et al., 2001).
As a follow up study they have established that in human prostate cancer cells, in which caveolin-1 alone failed to form plasma membrane caveolae, co-expression of caveolin-2 allowed for these organelles to form. Furthermore, They have also determined that serine phosphorylation of caveolin-2 appeared to be an important molecular mechanism via which caveolin-2 facilitates formation of fully invaginated caveolae in the presence of caveolin-1 (Sowa et al., 2003).

 

More information on Dr. Sowa and his lab can be found here.

Research Areas of Interest

Cancer
Cardiovascular biology/ research
Cell biology
Molecular genetics
Protein Biology