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Luis Martinez-Lemus , PhD

Assistant Professor, Department of Medical Pharmacology and Physiology, Dalton Investigator

 

Department of Medical Pharmacology and Physiology
252A Dalton Cardiovascular Research Center
Columbia, MO 65212
573-882-
MartinezLemusL@missouri.edu

 

Dr. Martinez-Lemus' research is focused on the mechanisms responsible for the architectural transformation of blood vessels also known as vascular remodeling. Vascular remodeling is a hallmark for numerous cardiovascular diseases, yet numerous questions remain to be answered regarding this process. What stimuli drive the remodeling process? How do blood vessels detect those stimuli? What are the mechanisms initiating the remodeling and under which conditions are they counterproductive participating in disease states?

 

Currently funded research in his laboratory is focused at determining the changes in the position and function of cells within the intact blood vessel wall that occur in response to common mechanical and vasoactive biochemical stimuli. His studies indicate that cells within the vascular wall rapidly change their position in response to stimulation in as little as four hours. This adaptive cell behavior appears to allow the vessel to maintain a reduced diameter for extended periods of time with reduced levels of activation and energy expenditure. An additional goal is focused at determining the changes in the structure and compliance of the extracellular matrix that occur during the initial stages of the remodeling process.

 

More information about Dr. Martinez-Lemus and his lab and be found here.

Research Areas of Interest

Cardiovascular biology/ research
Cell biology
Cellular signaling
Exercise
Exercise physiology
Membrane transport
Microvascular physiology
Physiological recordings
Signal transduction