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Ronald Korthuis, PhD

Chariman and Professor of Medical Phamacology and Physiology

Medical Pharmacology and Physiology
One Hospital Drive, MA415C
Columbia, MO 65212
573-882-8029
KorthuisR@health.missouri.edu

 

Dr. Korthuis' research focuses on the mechanisms underlying the inflammatory responses to ischemia and reperfusion (I/R) and how blood vessels in the microcirculation (arterioles, capillaries, and venules) can be preconditioned to resist the deleterious inflammatory effects I/R. When the blood supply is reduced (ischemia) and then subsequently reestablished (reperfusion), the ability of arterioles to regulate the distribution of blood flow is impaired, many capillaries fail to perfuse (capillary no-reflow), and white blood cells become adherent to and emigrate across the walls of postcapillary venules. In addition, the permeability of the cells lining capillaries and postcapillary venules is increased, leading to edema formation. They are studying how white blood cells which adhere to and emigrate across the walls of postcapillary venules alter vasoregulatory function in arterioles, cause no-reflow in capillaries, and increase permeability in postcapillary venules. Another line of investigation focuses on understanding how exposing tissues to preconditioning stimuli such as short periods of ischemia or ethanol (at doses equivalent to drinking one to two alcoholic beverages) 24 hours prior to the onset of prolonged ischemia followed by reperfusion prevents microvascular dysfunction. Using a variety of pharmacologic approaches and mutant mouse models, we are examining the signaling mechanisms that are triggered by exposure to preconditioning stimuli to induce the formation of protective proteins such as heme oxygenase.

 

More information about Dr. Korthuis and his lab can be found here.

Research Areas of Interest

Biological physics
Biomedical engineering
Cardiovascular biology/ research
Cell biology
Cellular signaling
Comparative physiology
Diabetes
Exercise
Exercise physiology
Immunocytochemistry EM/LM
Membrane transport
Microvascular physiology
PCR
Physiological recordings
Protein biology
Protein structure/function
Real-time PCR
Signal transduction