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Venkataseshu Ganjam, B.V.Sc., M.S., PhD

Professor of Veterinary Biomedical Sciences

University of Missouri-Columbia
E102 Veterinary Medicine Building
Columbia, MO 65211
573-882-7011
GanjamV@missouri.edu

 

Dr. Ganjam is currently the Director of the Hormone Assay Core and continues his work in elucidating the precise mechanisms involved in mammalian sperm maturation. Sperm acquire or develop the capacity for fertilization only during their transit through the epididymis, and knowledge of the sperm maturation process should enable its manipulation. The reversible prevention of sperm maturation, induction of premature cell death, or the binding of an "antifertilizing compound" to sperm within the epididymis might afford alterative methods for contraception.

 

The major functions carried out by the epididymis are the transport of spermatozoa, their maturation (acquisition of fertilizing potential), and their storage. The maturation of spermatozoa occurs by passage through the epididymis, and, depending on the species, is complete between the distal caput and the proximal cauda epididymis.

 

This process is active in that germ cells need to be exposed to the changing epididymal environment in order to become mature. Regarding the regulation of epididymal functions, several lines of evidence have come together to indicate that the primary androgen(s) responsible for maintaining epididymal histology and functions, is (are) the 5_-reduced metabolite(s) of testosterone, namely dihydrotestosterone (DHT) and/or its 3_-reduced form (3_-diol).

 

Dr. Ganjam and his lab are continuing their research studies on 1) factors regulating epididymal 5_-reductase activity, 2) distribution and kinetics of epididymal androgen receptors, and 3) to establish the interaction of androgen receptors and the gene expression of 5_-reductase.

 

More information on Dr. Ganjam and his lab can be found here.

Research Areas of Interest

Cell biology
Cellular signaling
Developmental Biology
Electrophysiology
Genetics
Hormone action
Hormone assay
Reproductive biology
Women's health

 

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