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Mike Davis, PhD

Professor, Medical Pharmacology and Physiology


Department of Medical Pharmacology and Physiology
University of Missouri-Columbia
One Hospital Drive, MA415
Columbia, MO 65212


The focus of Dr. Davis' research is on the mechanisms of mechanotransduction by blood vessels: How do vascular cells detect changes in pressure? What cellular proteins and signaling pathways are involved in this process? How are these mechanisms impaired in vascular disease states?


Currently, they are funded to investigate the intracellular signaling axis linking the extracellular matrix with integrin receptors, the cytoskeleton, and plasmamembrane ion channels. Their studies indicate that the L-type, voltage-gated calcium channel and the large-conductance, calcium-activated (BK) potassium channel are acutely regulated by integrins (adhesion molecules) in vascular cells, under both physiological and pathological conditions; ion flux through these channels subsequently controls the state of contraction of vascular smooth muscle.


The experimental approaches used in their laboratory include isolated, perfused microvessel methods and single-cell electrophysiology. They combine these with variety of imaging techniques, including confocal microscopy, atomic force microscopy, and total-internal reflectance fluorescence microscopy. They also use molecular analyses, such as site-directed mutagenesis and co-immunoprecipitation, to identify the specific integrin-associated proteins that are involved in the modulation of ion channels and to identify the specific domains on the channels that are required for their regulation.


More information on Dr. Davis and his lab can be found here.

Research Areas of Interest

Biological physics
Biomedical engineering
Cardiovascular biology/ research
Cell biology
Cellular signaling
Comparative physiology
Confocal fluorescence microscopy
Exercise physiology
Hormone action
Immunocytochemistry EM/LM
Membrane transport
Microvascular physiology
Physiological recordings
Protein biology
Protein structure/function
Real-time PCR
Signal transduction



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