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Douglas K. (Doug) Bowles, PhD

Director, Research Animal Angioagraphy Core, Associate Professor, Veterinary Biomedical Sciences, Dalton Investagator

University of Missouri-Columbia
E102 Veterinary Medicine Building
Columbia, MO 65211
573-882-7011
BowlesD@missouri.edu

 

Dr. Bowles is currently the Associate Director for the National Center for Gender Phsyiology, as well as the Director of the Research Animal Angioagraphy Core.

 

Dr. Bowles lab is interested in the role of vascular ion channels in adaptive responses to exercise, atherosclerosis and sex hormones (testosterone, estrogen). Their primary model is the pig, with an emphasis on coronary smooth muscle. The overall research question is how changes in ion channel function alter physiologic responses such as vasomotion, gene regulation and disease progression. Aside from standard patch-clamping and physiological measures, they are developing a line of research examining how ion channels regulate gene expression in smooth muscle with the goal of understanding how adaptive changes in ion channels alter smooth muscle phenotype during atherosclerosis.

 

They use whole-cell and patch clamp, isometric vessel recordings, cannulated microvessels, immunoblot and real-time PCR. They also have calcium imaging capabilies for both cells and cannulated microvessels. They have recently developed coronary smooth muscle cell and tissue culture models to fully take advantage of molecular biology tools (promoter/reporter constructs, etc) to examine gene regulation by ion channels.

 

They also have a state-of-the-art, fully digital cath lab exclusively for large animal (e.g. pig) research allowing us to do angiography, intravascular ultrasound, intracoronary flow and pressure. They can also induce coronary injury/restenosis with balloons and stents with the goal to provide direct, in vivo, "translational" endpoints to our cellular/genetic studies.

 

More information on Dr. Bowles and his Lab can be found here.

Research Areas of Interest

Cardiovascular biology/ research
Cell biology
Cellular signaling
Electrophysiology
Exercise
Exercise physiology
Hormone action
Membrane potentials
Membrane transport
Microvascular physiology

 

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